![]() As a result, this album never stops winning". On Occult Classic, Kill The Noise turns left, shoots straight, and never stops scoring. Marcus Dowling of LessThan3 generally liked the album, stating: "When veteran DJs become inventive producers, the opportunity for well-delivered, sometimes fanciful, and consistently fantastic productions emerges. Lucas Sachs of Your EDM described the song as Dolphinstep and noted the song for its "Skrillex-esque bounce vibe". On the other hand, David Klemow described "Dolphin on Wheels" as "an entire season of Spongebob Squarepants packed into a song", further stating: "Kill The Noise reserves a spot on his introductory record for a quick little jab at electronic music, pulling in perennial prankster Dillon Francis on the gag". Michael Sundius of Dancing Astronaut described "I Do Coke"'s music video a "stirring visual narrative to the song's oft-overlooked satire", stating: "As you'd expected from the off-kilter collaboration, the video is a dark, drug-induced thrill ride that only gets stranger as it goes on". Reception and release ĮDM.com reviewed "Kill It 4 The Kids", stating "The track is a headbanging piece of EDM thrash, featuring his heavily distorted signature synth work, hard-hitting trap beats, and shouted vocal samples". Problems playing this file? See media help. The main character in this story has found himself stuck on an endless merry-go-round that goes nowhere. In this story, the message is that if you aren't careful, you can become figuratively (and literally) consumed by your lifestyle of addiction. ![]() Stanczak clarified the music video's intentions, stating: which was criticised for its glorification of drug usage. The song was released alongside a music video directed by Brandon Dermer, produced by Anthem Films, and stars Tom Sandoval as a cocaine abuser. ![]() On 4 April 2015, OWSLA released a collaboration between Kill the Noise and Feed Me titled I Do Coke as the first single from Stanczak's upcoming album, Occult Classic. Creatively, that's just a really restrictive place to be. Especially in dance music, people just want to get their head blown off in the first 15 seconds. There's all these demos that I had been writing that I had been afraid to put more time into because I didn't feel like it was stuff that people would understand. I had ended up in a place where I started feeling like I was rewriting stuff that I'd already done before. In an interview with Nick Murray of Rolling Stone, Stanczak commented on his musical direction he has taken for Occult Classic, stating: They're never a huge departures but they're clearly different directions. The thing is, if you follow my Kill The Noise stuff since 2007 you’ll know it's always changing. I wanted something that lasted and was a bit clever. I went through so many ideas over the last year and a half. I had all these ideas and tried a bunch of things and wrote names and had it pretty much decided. In an interview with Dave Jenkins of UKF, Stanczak commented on the album title and artwork style, stating: ![]() And after close to a year of trying to balance the two, I started to realize, if I'm really serious about putting an album together, I’ve got to pull myself off the road for a period of time to really go in and get a vibe. I had been working on a bunch of new ideas, and I guess there was a point where I was like, "this is definitely something." The first nine months or so was just me really trying to find time to work in the studio - I was doing a lot of touring. I started working on the album close to two years ago. In an interview with Elias Leigh of Billboard, Stanczak commented on the start of the production process of Occult Classic, stating: Occult Classic was later followed up by a 15-track remix album titled Alt Classic (stylised as ALT CLASSIC) released on. Occult Classic was released on 9 October 2015, by American electronic music label Owsla. Occult Classic (stylised as OCCULT CLASSIC) is the debut studio album by American electronic music producer Kill the Noise. ![]()
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![]() ![]() This tool is mainly white, with purple trim, and is actually the same size and shape as the orange peeler (it just lacks the slot in the middle).ĭo you love strawberries? Strawberry tarts? Strawberry smoothies? Strawberries in your breakfast cereal? Of course you do strawberries are delicious. Just use the small sharp hook at the tip of the tool to score two lines into the peel from the top to the bottom to form a wedge, then insert the tapered corner of the tool to separate the peel in that slice, and fold it down. Similarly, the Chef'n Peel'n Onion Peeler is a small BPA-free plastic device designed to remove the skins from onions while minimizing odor to your fingernails or hands, because with it you only have to hold the exterior layer at the bottom in one hand while cutting and separating the peel with the other. Dimensions: 5 inches long, and up to 3 inches wide Just pierce the rind into sections with the "mini-hook" at its tip, then lift a section of peel with one of its tapered corners, and slip it into the slot, and keep sliding around the fruit to completely remove the peel. Made of BPA-free plastic, and shaped somewhat like a bottle opener, this lightweight tool with a rounded ergonomic handle makes it easy to penetrate the peel and quickly remove it in sections without needing to claw at it with your fingernails or leaving rind in them. Our product range also includes a pocket knife for horologists with a tool for opening watch cases and a pocket knife for bakers that includes a baker's blade.The ZeelPeel Orange Peeler makes peeling citrus easy, without chipping or taxing your fingernails. Our fishing pocket knife comes equipped with, for example, a fish scaler and a hook disgorger, while our pocket knife for mountaineers displays the time, temperature and altitude. Over time, they have become outright specialists. Made for special occasions: Our pocket knives are not just generalists. Over the years, we have also added features like a USB stick and an integrated stopwatch. ![]() Our wooden scales are also very comfortable to hold. For instance, we now have new ergonomically shaped pocket knife scales which sit particularly well in the hand. That is because we are always developing new pocket knives and functions. But no one has yet accused us of resting on our laurels. Given clear instructions and a few safety rules, of course, just let them get started! Our pocket knives for children have rounded blades so you can be reassured that you are not exposing your children to any unnecessary risks.Īlways up for something new? Yes, it is true, we have been making the same thing for over a century: pocket knives. That is why we believe it is so important for young children to be able to use pocket knives and experience just how much creativity they inspire. If that is still not enough for you, we recommend our pocket knife with, believe it or not, 81 integrated functions.įor children: We love skilled crafts. Pliers and even an entire set of Allen keys are also at your disposal. The integrated magnifying glass is there to assist you with any extreme precision work. But did you know that our pocket knives can also perform completely different tasks? For example, stripping a wire. You may also know that some Swiss Army Knives come with a wood saw, scissors or awl. Let us tell you about some of the other ways our pocket knives can be used.Īlways prepared: You are no doubt familiar with the basic functions of our pocket knives: blade, can opener, bottle opener, screwdriver, corkscrew, tweezers and toothpick. Made up of 64 individual components, it passes through 450 stages of production. The top-of-the-range model of pocket knife, the Swiss Champ, for example, combines 33 functions in one award-winning design. The Swiss Army Knive has become an icon and is regarded as the embodiment of multifunctionality, inventiveness and Swiss precision. His pocket knife can now be found exhibited in museums around the world, including the Museum of Modern Art in New York. On 12 June 1897, Victorinox founder Karl Elsener patented his Officer’s Knife and Sports Knife. ![]() ![]() ![]() They would offer no special bonuses for having the full set equipped. The fee to unlock the PvP armours, making them wearable but untradeable, would be as follows:Įach piece of the PvP armour sets would require 80 Defence to equip and would last for 1 hour of combat before fully disintegrating. This means that in any Player vs NPC (PvM) activity, you would only gain the defensive bonuses of the gear. We want to offer the PvP armours as a more exclusive PvP item so we’d like to propose them as having no offensive bonuses when not attacking a player. However, PvP armours can never be repaired - once they degrade they disintegrate and leave the game entirely! Much like Barrows equipment, these items degrade. Each piece of the PvP armours are tradeable but they cannot be equipped until a fee has been paid - once this fee is paid the item will instantly become wearable, but is no longer tradeable. ![]() Known to be some of the best defensive gear in the game, they come with a great cost. You can then decide whether or not it's worth getting rid of one of your existing keys for one on the floor, etc.īy far the most iconic drops the Revenants had were the Ancient Warrior's equipment (also known as PvP armour and weapons). Keys would have an "Inspect" option on them, this option is available while they are on the floor or in your inventory.You will still need to run over and pick it up. When killing a player with Loot Keys enabled, the key would be dropped in the way you'd expect normal loot to drop from a kill.Keys can be redeemed at a bank, similar to Deadman keys, or destroyed.A player can hold up to 5 keys at once, after which PvP drops will revert to normal functionality until they have either redeemed or destroyed a key.Loot keys turn all the loot you'd normally get from a player in the wilderness or PvP worlds into the form of a key, which will only use up 1 inventory slot.The Loot Key Scroll is a new tradeable item dropped by Revenant NPC's found within the Revenant Caves which can be redeemed at Krystilia (the Edgeville witch), giving players the ability to toggle "Loot keys". Instead of applying scaling stats, the amulet would simply apply a scaling flat damage boost to all attack styles (Melee, Ranged and Magic) from +0% when uncharged, to +20% when fully charged. The amulet when uncharged would have the same offensive stats as an Amulet of fury, however, these stats would not change based on your % of hitpoints missing. This means it will not work when fighting against NPC's but will provide great bonuses for anyone in a PvP situation that is willing to risk having lower hitpoints. Players will need to have the amulet equipped and be in combat with another player for a set amount of time to “charge” it before strength bonus kicks in. The Amulet of Peril is a new tradeable rare drop from Revenant NPC's which has the ability to increase your strength bonus based on how low your active hitpoints are whilst in PvP combat. What if the same concept could be applied to gear? We wanted the Revenant caves to be high risk, high reward in terms of loot. ![]() ![]() ![]() ![]() This is three weeks earlier than the original date scheduled to close, Sept. At least 8 other markers are within walking distance of this marker.MACKINAW CITY - Historic Mill Creek Discovery Park will close for the 2022 season on Aug. Marker is in this post office area: Mackinaw City MI 49701, United States of America. Marker is at the driveway to Star Line Ferry parking. Marker is at the intersection of South Huron Avenue and Railroad Avenue, on the right when traveling north on South Huron Avenue. Marker is in Mackinaw City, Michigan, in Cheboygan County. A significant historical year for this entry is 1780. This historical marker is listed in these topic lists: Colonial Era Source: Archaeological Completion Report Series, Number 10, Mackinac State Historic Parks, 1985 (Marker Number 6.) At the park, visitors enjoy the museum, nature trails and demonstrations of the reconstructed dam and sawmill. The site was acquired by Mackinac State Historic Parks in 1975 and opened to the public as an historical park in 1984. Archaeological excavations beginning inġ973 confirmed that the site was the frontier mill of Robert Campbell and Michael Dousman. Three avocational archaeologists from Cheboygan, Ellis Olsen, Mary Olsen and Margaret Lentini are credited with re-discovering the site in 1972. It is unknown exactly when Mill Creek was abandoned, but local history places the date around 1839. Dousman continued supplying the garrison with lumber, and expanded the enterprise to include other provisions such as beef, flour, barrels and hay. Robert Campbell died in 1808 and his heirs eventually sold the property to Michael Dousman for one thousand dollars. Over the years, lumber from Campbell's mill was used to construct many of the buildings on Mackinac Island, including Mission Church. A small stream on the property provided enough water to power a mill for several minutes each day during the spring and early summer. Sinclair granted private claim 334, consisting of 640 acres south of Fort Michilimackinac to Robert Campbell. When Patrick Sinclair moved Fort Michilimackinac from the mainland to Mackinac Island in 1780, he recognized the need for a saw mill to provide lumber for the new fort and adjoining community buildings. This historical marker is in Mackinaw City in Cheboygan County Michigan ![]() ,, Source: Archaeological Completion Report Series, Number 10, Mackinac State Historic Parks, 1985. Archaeological excavations beginning in 1973 confirmed that the site was the frontier mill of Robert Campbell and Michael Dousman. ,, It is unknown exactly when Mill Creek was abandoned, but local history places the date around 1839. ,, Over the years, lumber from Campbell's mill was used to construct many of the buildings on Mackinac Island, including Mission Church. , When Patrick Sinclair moved Fort Michilimackinac from the mainland to Mackinac Island in 1780, he recognized the need for a saw mill to provide lumber for the new fort and adjoining community buildings. ![]() ![]() ![]() Following completion of his training, Dr. Wong completed his ophthalmology residency and vitreoretinal fellowship at the world-renowned Wills Eye Hospital in Philadelphia. ![]() After earning his medical doctorate (M.D.) with honors from Baylor, Dr. He then attended Baylor College of Medicine where he was a recipient of the President’s Scholar Award, which is given to the top seven students entering the medical school class and earned a place in the Alpha Omega Alpha Honor Medical Society. Wong was one of nine students elected to Phi Beta Kappa as a junior. Graduating with honors from Johns Hopkins University in Baltimore, Dr. Wong has access to the latest digital scanners, ophthalmology technology, and diagnostic tools so he can create the best treatment plan for his patients. As a member of Retina Consultants of Texas's renowned team of surgeons, Dr. He works with patients to help them manage age-related macular degeneration, as well as diabetic retinopathy - two retinal diseases that do not have a definitive cure and require ongoing treatment and evaluation. Wong performs the latest surgical techniques to treat a number of vitreoretinal disorders, including retinal tears and detachments, macular holes and puckers, vitreous hemorrhages, and vascular occlusions. ![]() Common Eye Surface Problems - Blepharitis, Dry Eye, Subconjuntival Hemorrhageĭr.Idiopathic Parafoveal Telangiectsasia (PFT).Central Serous Retinopathy / Chorioretinopathy.Retinal Artery Occlusion (CRAO and BRAO).Peripheral Retinal Pathology - Lattice Degeneration, White Without Pressure, Pigmented Lesions and Masses.Panretinal Photocoagulation (PRP) Laser. ![]() ![]() ![]() Apr 14th 2023 AMD Brings ROCm to Consumer GPUs on Windows OS (21).May 3rd 2023 AMD's Radeon RX 7800 XT Spotted in Geekbench Vulkan Test (8).Jun 20th 2023 NVIDIA H100 Hopper GPU Tested for Gaming, Slower Than Integrated GPU (24).Heaven Benchmark comes in three editions: Basic (available for free), Advanced and Pro, each aimed to meet the needs of different users. New Advanced edition (see details below).Enhancement of automation scripts in Pro version.New, improved version of UNIGINE Engine under the hood.Benchmarking presets for convenient comparison of results.Support for multi-monitor configurations and different stereo 3D modes.Real-time global illumination and screen-space ambient occlusion.Dynamic sky with volumetric clouds and tweakable day-night cycle.Cinematic and interactive fly/walk-through camera modes.Comprehensive use of hardware tessellation, with adjustable settings. ![]() Multi-platform support for Windows, Linux and Mac OS X.Support for DirectX 9, DirectX 11 and OpenGL 4.0.Accurate results due to 100% GPU-bound benchmarking.An interactive experience with fly-by and walk-through modes allows for exploring all corners of this world powered by the cutting-edge UNIGINE Engine that leverages the most advanced capabilities of graphics APIs and turns this benchmark into a visual masterpiece.ĭOWNLOAD: Unigine Heaven 4.0 for Windows, Mac OS X, Linux Nested on flying islands, a tiny village with its cozy, sun-heated cobblestone streets, an elaborately crafted dirigible above the expanse of fluffy clouds, and a majestic dragon on the central square gives a true sense of adventure. Heaven Benchmark immerses a user into a magical steampunk world of shiny brass, wood and gears. It provides completely unbiased results and generates true in-game rendering workloads across all platforms, such as Windows, Linux and Mac OS X. This powerful tool can be effectively used to determine the stability of a GPU under extremely stressful conditions, as well as check the cooling system's potential under maximum heat output. has released a new, enhanced version 4.0 of Heaven Benchmark, the GPU intensive benchmark that gained massive popularity among overclockers and hardware manufacturers for hammering their graphics cards to the limits. ![]() ![]() ![]() ![]() Their ice cream is homemade, perfectly prepared, and hand-dipped, the coffee is tasty and completely flavored, the aroma is everywhere in the restaurant as you enter. There are over 32 samples of different ice cream flavors to choose from, and they also have desserts, high ceilings, large pillars, keto cupcakes, gourmet chocolates, truffles, turtles, and caramel, and many more. ![]() Locals and tourists always come here for some ice creams and sweet coffee. Sweet Caroline is situated in Joplin Main Street in a lovely Historic Gryphon Building. Sweet Caroline’s, Joplin, Missouri Credits: Atsushi Hirao / Shutterstock You can bring along the kids too to have some fun.Īddress: 510 Kentucky Ave, Joplin, MO 64801 4. You can buy as many delicious sweets as possible, and there are many varieties to choose from. In Spring time, they offer recently made strawberries immersed in chocolate. In the fall season, they have different types of sweets prepared from seasons and fresh apples available for people. Seasonal desserts are also available in the Candy house. The Candy House is popularly known for its chocolates, gourmet creams, caramels, chocolate truffles, fudges, jellies, and other delicious items. The Shop has a vast array of desserts to choose from that’ll satisfy your cravings for tasty sweets. The place has been the number one spot for locals and visitors to enjoy tasty candy. The Candy House Gourmet is situated in the downtown region of Joplin and is more of a candy factory. Satisfy Your Sweet Tooth At Candy House Gourmet Credits: Ruth Black / Shutterstock The long line of the history of these two has been preserved, so tourists come and see for themselves how they lived their lives.Īddress: 299 W 34th St #201, Joplin, MO 64804, 3. You can have some photos too outside the house to post on your Instagram account. ![]() The apartment is currently used as an Airbnb, you can live in the apartment Bonnie and Clyde once stayed in. You can visit the apartment to have a firsthand view of how the hideout looks like and why they chose this particular house as a hideout to carry out their nefarious activities. The romantic couples were known for engaging in robbery operations and various killings in the region. Bonnie and Clyde’s Joplin Garage Apartment Hideout Credits: AbeEzekowitz, Wikimedia Commonsīonnie and Clyde’s Joplin Garage Apartment HideoutThe Garage and Apartment hideout was home to two notorious criminals, Bonnie and Clyde. The Grand falls is a sure place to visit when you’re in Joplin and should be on your checklist of fun things to do in J0plin.Īddress: 5685 Riverside Dr, Joplin, MO 64804, 2. It is advisable not to put on strong shoes as the land is bumpy. The place also features private swimming pools where friends and families can have a nice time together and still enjoy the view of the waterfall.ĭon’t forget to bring along your camera to capture the outstanding beauty of the waterfall and some great pictures to post on your installed account. No matter what time of the year or season you intend to visit, you’ll find the waterfall flowing because of the creek that never runs out of water. The waterfall offers outstanding views of the picturesque surroundings. The Grand falls is a famous attraction to find in the region. The Grand falls is situated in Shoal Creek, The waterfall to be found here in Missouri is one of the biggest continual flowing waterfalls. Visit Grand Falls Credits: Jeffrey L Watson / Shutterstock Here are some of the best places to see and things to do in Joplin, MO. All the restaurants and cafes serve delectable American food. The food scene in this city is incredible as well. Joplin has fascinating museums, splendid parks, charming antique malls, a fantastic waterfall, and so much more. Joplin is located at the beginning of the historic and scenic Route 66 It is a popular tourist attraction among travelers because of its breathtakingly impressive natural beauty and rich history and culture. This small charming town is located in the counties of Jasper and Newton. of A’s beautiful state of Missouri, Joplin or the City of Joplin is a lovely picturesque town. Perched in the northwestern part of the U.S. In search of the Best & fun things to do in Joplin, MO? this city sure has some cool attractions and activities to give you a fun time. ![]() ![]() ![]() You only get 30 minutes to approve the extension. In most (all?) cases, this is due to a poorly written 3rd party driver. Not sure if this was due to Gatekeeper/macOS or how the developer released/packaged the app & driver. I know that sometimes the driver portion of the install must be approved separately. I know that at least two times I had to reboot multiple times and approve the driver multiple times before macOS accepted the configuration. I believe I may have once approved the driver by right-clicking or Control-clicking the actual installed app, but that was a while ago so I don't recall. I know a couple of times it was not straight forward even when the "Allow exception" button was available in the Gatekeeper Security settings (the button did not always show up). I don't install many apps utilizing drivers, so I forget how I've handled it in the past. The one user did mention the software was installing a driver. ![]() Just right-click or control-click on the thing you want to run and choose "Open" from the context menu. If you want to install something, something that you trust, or something that you shouldn't, you can always override Apple's productions. ![]() ![]() ![]() Ludacris served as an intern and then a DJ at Atlanta's Hot 97.5 (now Hot 107.9) under the name "Chris Lova Lova". Music career 1998–2000: Incognegro and Back for the First Time Ludacris wrote his first rap song at age nine when moving to Atlanta, Georgia, and joined an amateur rap group three years later. He is a distant cousin of late comedian Richard Pryor. Ludacris' parents are both African American, and he also has more distant English and Native American ancestry. From 1998 to 1999, he studied music management at Georgia State University. He attended Banneker High School in Atlanta, Georgia and graduated in 1995. After attending Oak Park River Forest High School in ninth grade, Ludacris moved to Centreville, Virginia and attended Centreville High School for one year. ![]() Throughout his career, Ludacris has won three Grammy Awards, a Screen Actors Guild Award, a Critic's Choice Award and an MTV Video Music Award.īorn Christopher Brian Bridges in Champaign, Illinois, Ludacris moved to Oak Park as a teenager. He is often cited as one of the first Dirty South rappers to achieve mainstream success in the 21st century, with several commercially and critically successful studio albums. In 2021, Bridges created his own children's musical television series for Netflix known as Karma's World, in which he also served as a voice actor. His other notable roles include Crash (2004), Gamer (2009), and New Year's Eve (2011). His seventh album, Battle of the Sexes (2010), featured a return to the more lighthearted tone of his previous albums.Īs an actor, Ludacris is best known for his role as Tej Parker in the Fast and Furious film series, with his first appearance in the franchise coming in the 2003 film. In 2010, he was featured on Justin Bieber's single " Baby", which became one of the highest-certified singles of all time in the US and a defining song in modern-day popular music. His next two albums Release Therapy (2006) and Theater of the Mind (2008), explored more serious content than its predecessors. He then released the albums Word of Mouf (2001), Chicken-n-Beer (2003) and The Red Light District (2004), all of which were certified multi-platinum by the Recording Industry Association of America (RIAA). The singles " Southern Hospitality" (featuring Pharrell) and " What's Your Fantasy" (featuring Shawnna), became top 40 hits on the Billboard Hot 100 chart. The album was repackaged and re-released for his major label debut Back for the First Time, after he signed with Def Jam Recordings. Starting out with a brief stint as a DJ, he formed his own record label, Disturbing tha Peace in the late 1990s, and his first album Incognegro (1999). Born in Champaign, Illinois, Ludacris moved to Atlanta, Georgia, at age nine where he first began rapping. ![]() Christopher Brian Bridges (born September 11, 1977), known professionally as Ludacris ( / ˈ l uː d ə k r ɪ s/, homophonous with 'ludicrous' in American English), is an American rapper and actor. ![]() ![]() All of the conditions and diseases mentioned above involve the cAMP signaling pathway and its branch pathway. Second messenger pathways are associated with numerous conditions and diseases, including inflammation ( 6, 7), cancer ( 8, 9), myocardial atrophy ( 2), asynodia ( 10) and depression ( 11). Phosphodiesterases (PDEs) are an enzyme superfamily that have been demonstrated to catalyze the hydrolysis of intracellular second messenger molecules, including cAMP and cGMP therefore, the inactivation of PDE will indirectly increase the level of cAMP in cells ( 5). Extracellular signals activate the transcription of a variety of target genes via alterations in CREB phosphorylation, thereby, resulting in multiple physiological functions ( 4). The phosphorylation of the cAMP response-element binding-protein (CREB), a transcription factor, is important in the regulation of gene transcription ( 3). Subsequently, specific proteins are phosphorylated by PKA ( 2) to evoke cellular reactions. ![]() 1.Īdenylate cyclase (AC) converts adenosine triphosphate (ATP) into cAMP, which stimulates cAMP-dependent protein kinase A (PKA). Signal response factors associated with cAMP are discussed below and the current understanding of the cAMP signaling pathway is presented in Fig. This review focuses primarily on reviewing cAMP, an important second messenger, and the associated cell signal transduction pathway. It has been identified that numerous signaling pathways are triggered by second messengers including cAMP, diacylglycerol, inositol triphosphate (IP 3), cGMP and Ca 2+. The degradation of these second messengers leads to signal termination. Second messengers convert and amplify extracellular signals by activating protein kinases that serve physiological roles or by acting on intracellular ligand-gated channels to alter the membrane potential. ![]() cAMP, adenosine 3′,5′-cyclic monophosphate PKA, protein kinase A CRE, cAMP response-element CREB, CRE binding-protein NO, nitric oxide cGMP, cyclic guanosine monophosphate PKG, protein kinase G IP3, inositol triphosphate PKC, protein kinase C PDE, phosphodiesterase iNOS, inducible nitric oxide synthase AC, adenylate cyclase GC, guanylyl cyclase PLC, phospholipase C CaM, calmodulin RIA, radioimmunoassay ELISA, enzyme-linked immunosorbent assay HPLC-MS, high performance liquid chromatography-mass spectrometry CTX, cholera toxin RT-PCR, reverse transcription-quantitative polymerase chain reaction ChIP, chromatin immunoprecipitation EMSA, electrophoretic mobility shift assay SAM, S-adenosylmethionine IBMX, 3-isobutyl-1-methylxanthine. The detection methods, inhibitors and activators of cAMP, PKA, PDE and CREB in the cAMP-PKA-CREB pathway are depicted. ![]() The figure presents three second messengers involved in three signal transduction pathways, including cAMP-PKA-CREB, NO-cGMP-PKG and IP3-Ca 2+-PKC. Schematic diagram of second messenger signaling pathways. ![]() |
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